Introduction. Gastric cancer (GC) is one of the most common malignancies in the world, with an annual incidence of about one million, making it the fifth most common cancer and the third leading cause of cancer-related deaths worldwide. 1, 2 The highest rates of estimated morbidity and mortality have been observed in Eastern Asian countries. 1Purpose Capecitabine has demonstrated high efficacy as first-line treatment for metastatic colorectal cancer (MCRC). Oxaliplatin shows synergy with fluorouracil (FU), with little toxicity overlap. The XELOX regimen (capecitabine plus oxaliplatin), established in a previous dose-finding study, should improve on infused oxaliplatin with FU and leucovorin (FOLFOX) regimens. The present studies ...Sep 21, 2016 · Purpose Capecitabine has demonstrated high efficacy as first-line treatment for metastatic colorectal cancer (MCRC). Oxaliplatin shows synergy with fluorouracil (FU), with little toxicity overlap. The XELOX regimen (capecitabine plus oxaliplatin), established in a previous dose-finding study, should improve on infused oxaliplatin with FU and leucovorin (FOLFOX) regimens. The present studies ... In comparison to other creators in our database, @Xleox is ranked Golden Publiseh (Top 10%), showcasing their exceptional performance and engagement. The content output of Xleox are remarkable, with over 504 photos and 335 videos shared!FOLFOX chemotherapy, also called Oxaliplatin de Gramont (OxMdG), is a type of cancer therapy that involves taking drugs containing anticancer chemicals. These chemicals target rapidly dividing ...XLeox @iamxleox. Fitness Onlyfans Adult Massdm Xleox Shoutout. Description. Oner of the biggest Onlyfans male pages with over 30K fans in total (7K paid atm) https ... Oxaliplatin and capecitabine (XELOX) Oxaliplatin and capecitabine is a chemotherapy combination known as XELOX. This combination might also be called CAPOX, CAPE-OX or OxCap. It is a treatment for bowel cancer (colorectal cancer). Xerox VersaLink B7100 Series Multifunction Printers. Xerox ® ConnectKey ® technology enabled Workplace Assistant that can do it all. Black-and-white MFP with support for Tabloid. Copy, print, scan, fax, email, cloud. Tablet-like intuitive user interface lets you personalize, simplify and speed through repetitive tasks.OnlyFans is the social platform revolutionizing creator and fan connections. The site is inclusive of artists and content creators from all genres and allows them to monetize their content while developing authentic relationships with their fanbase. Background: XELOX plus bevacizumab (XELOX-Bev) and FOLFIRI plus Bevacizumab (FOLFIRI - Bev) treatments are an effective strategies patients with metastatic colorectal cancer (mCRC).The aim of this study was to compare efficacy of first-line XELOX-Bev treatment vs FOLFIRI-Bev treatment for mCRC.Mar 29, 2022 · At least 1 in 5 individuals receiving FOLFOX treatment develop some or all of the following side effects: gastrointestinal issues, such as diarrhea, nausea, and vomiting. neurological issues, such ... Xleox has a remarkable 797 publications, and their most recent activity was logged as 16 minutes ago. In comparison to other creators in our database, @Xleox is ranked Golden Publiseh (Top 10%), showcasing their exceptional performance and engagement. The content output of Xleox are remarkable, with over 504 photos and 335 videos shared! 4014 Background: At present, there is no standard chemotherapy regimen for advanced gastric cancer (AGC), and there is no consensus whether the three-drug combination is better than two-drug combination in first-line treatment. Both of XELOX regimen and EOX regimen are widely recommended as firs-line chemotherapy regimens for AGC. In this EXELOX trial, we aimed to compare the efficacy and ... Outpatients with histologically confirmed colorectal cancer that was metastatic and had progressed during or within 6 months after first-line chemotherapy for metastatic disease with an irinotecan-based regimen (i.e. irinotecan plus 5-FU/FA or irinotecan, 5-FU/FA and a targeted biological agent) were enrolled. XELOX (or CAPOX) is used to treat bowel cancer. It is best to read this information with our general information about chemotherapy and the type of cancer you have. XELOX and CAPOX are different names for the same combination of chemotherapy drugs. They are named after the initials of the drugs used for treatment.따라서 현재 젬시타빈 기반의 항암치료에 병이 진행한 국소진행성 혹은 전이성 췌장암 환자에서 2차 치료로서 폴폭스, 젤록스 및 젤로다 단독 항암치료를 사용해 볼 수 있다. 존재하지 않는 이미지입니다. 투여 계획은 일반적으로 세 가지 항암제를 2~3일 동안 매 ...Purpose Capecitabine has demonstrated high efficacy as first-line treatment for metastatic colorectal cancer (MCRC). Oxaliplatin shows synergy with fluorouracil (FU), with little toxicity overlap. The XELOX regimen (capecitabine plus oxaliplatin), established in a previous dose-finding study, should improve on infused oxaliplatin with FU and leucovorin (FOLFOX) regimens. The present studies ...10.3109/07357907.2015.1104689. This meta-analysis aims to evaluate chemotherapy with XELOX (capecitabine plus oxaliplatin) versus FOLFOX (fluorouracil plus oxaliplatin) as a treatment for metastatic colorectal cancer (mCRC) in terms of efficacy and safety. Only randomized controlled trials (RCTs) comparing XELOX versus FOLFOX were included. The mXELOX adjuvant chemotherapy presented a comparable survival benefit and lower incidence of toxicity than standard XELOX chemotherapy. It could be an alternative treatment for high-risk patients with operated stage III colon cancer.Objective: The combination of oxaliplatin and oral capecitabine (XELOX) has shown to be an active regimen in metastatic colorectal cancer (MCRC). However, the experience with XELOX in elderly patients is limited.All my links, social media, and more! | Fitness & more 👅 ️ | OnlyFans 🔞 70% Biggest sale EVER🔥 | Leo (@leolemento) • Instagram photos and videos Feb 25, 2022 · There is no consensus on whether triplet regimen is better than doublet regimen in the first‐line treatment of advanced gastric cancer (AGC). We aimed to compare the efficacy and safety of oxaliplatin plus capecitabine (XELOX) and epirubicin, ... Efficacy and safety of trastuzumab in combination with oxaliplatin and fluorouracil-based chemotherapy for patients with HER2-positive metastatic gastric and gastro-oesophageal junction adenocarcinoma patients: a retrospective studyToo help even it out I decided to pick up a guy's onlyfans! That guy is leo aka xleox and he is a mostly male onlyfans creator. He does some guy girl stuff m...Xleox has a remarkable 797 publications, and their most recent activity was logged as 16 minutes ago. In comparison to other creators in our database, @Xleox is ranked Golden Publiseh (Top 10%), showcasing their exceptional performance and engagement. The content output of Xleox are remarkable, with over 504 photos and 335 videos shared! Buying romeo twinks onlyfans so you don't have to My OF: https://linktr.ee/stanchrisromeo ig: @romeo18_private🌈Become a member for a shoutout in every video... Introduction. Gastric cancer (GC) is one of the most common malignancies in the world, with an annual incidence of about one million, making it the fifth most common cancer and the third leading cause of cancer-related deaths worldwide. 1, 2 The highest rates of estimated morbidity and mortality have been observed in Eastern Asian countries. 1Sep 21, 2016 · Purpose Capecitabine has demonstrated high efficacy as first-line treatment for metastatic colorectal cancer (MCRC). Oxaliplatin shows synergy with fluorouracil (FU), with little toxicity overlap. The XELOX regimen (capecitabine plus oxaliplatin), established in a previous dose-finding study, should improve on infused oxaliplatin with FU and leucovorin (FOLFOX) regimens. The present studies ... Oct 16, 2019 · Background A fixed 8-cycle oxaliplatin and capecitabine (XELOX) regimen has been the standard adjuvant therapy for patients with stage III colon cancer. However, completing the full-cycle of oxaliplatin is often associated with severe neurotoxicity. To spare patients from the toxic effects, without comprising the required efficacy, we evaluated the safety and efficacy of a modified XELOX ... Xleox has a remarkable 797 publications, and their most recent activity was logged as 16 minutes ago. In comparison to other creators in our database, @Xleox is ranked Golden Publiseh (Top 10%), showcasing their exceptional performance and engagement. The content output of Xleox are remarkable, with over 504 photos and 335 videos shared! 67K Followers, 20 Following, 50 Posts - See Instagram photos and videos from (@xleoxdaily) 4001 Background: The combination of PD-1 antibody and chemotherapy was shown to be effective in advanced gastric or gastro-oesophageal junction (GEJ) cancer, but has not yet been investigated in the context of locally advanced patients. In this study, we conducted a prospective, randomized, open-label phase II trial to evaluate the effectiveness of adding PD-1 antibody to perioperative ...10.3109/07357907.2015.1104689. This meta-analysis aims to evaluate chemotherapy with XELOX (capecitabine plus oxaliplatin) versus FOLFOX (fluorouracil plus oxaliplatin) as a treatment for metastatic colorectal cancer (mCRC) in terms of efficacy and safety. Only randomized controlled trials (RCTs) comparing XELOX versus FOLFOX were included. Leonhard Stuke is single. She is not dating anyone currently. Leonhard had at least 1 relationship in the past. Leonhard Stuke has not been previously engaged. His full name is Karl Leonhard Stuke, and he is from Germany. According to our records, she has no children. Like many celebrities and famous people, Leonhard keeps her personal and love ...Subscribe to be the first to know about new content.. @Iamxleox. Telegram channel 🔞XELOX (or CAPOX) is used to treat bowel cancer. It is best to read this information with our general information about chemotherapy and the type of cancer you have. XELOX and CAPOX are different names for the same combination of chemotherapy drugs. They are named after the initials of the drugs used for treatment.The IDEA clinical consensus recommends a risk-based approach in deciding on the duration of adjuvant therapy. [6,7] For patients with low-risk stage III colon cancer (T1-3, N1), 3 months of CAPOX adjuvant chemotherapy is appropriate. For patients with high-risk stage III colon cancer (T4 and/or N2 or other high-risk factors), 6 months of ...The mXELOX adjuvant chemotherapy presented a comparable survival benefit and lower incidence of toxicity than standard XELOX chemotherapy. It could be an alternative treatment for high-risk patients with operated stage III colon cancer.Pre- and post-chemotherapy images of a T3 N1 M0 cStage IIIa colorectal cancer. Four courses of CAPOX therapy. CAPOX (also called XELOX [1]) is a chemotherapy regimen consisting of capecitabine ( trade name Xeloda) combined with oxaliplatin. [2] [3]Xerox VersaLink B7100 Series Multifunction Printers. Xerox ® ConnectKey ® technology enabled Workplace Assistant that can do it all. Black-and-white MFP with support for Tabloid. Copy, print, scan, fax, email, cloud. Tablet-like intuitive user interface lets you personalize, simplify and speed through repetitive tasks.All my links, social media, and more! | Fitness & more 👅 ️ | OnlyFans 🔞 70% Biggest sale EVER🔥 | Leo (@leolemento) • Instagram photos and videosPurpose Capecitabine has demonstrated high efficacy as first-line treatment for metastatic colorectal cancer (MCRC). Oxaliplatin shows synergy with fluorouracil (FU), with little toxicity overlap. The XELOX regimen (capecitabine plus oxaliplatin), established in a previous dose-finding study, should improve on infused oxaliplatin with FU and leucovorin (FOLFOX) regimens. The present studies ...At least 1 in 5 individuals receiving FOLFOX treatment develop some or all of the following side effects: gastrointestinal issues, such as diarrhea, nausea, and vomiting. neurological issues, such ...XLeox @iamxleox. Fitness Onlyfans Adult Massdm Xleox Shoutout. Description. Oner of the biggest Onlyfans male pages with over 30K fans in total (7K paid atm) https ... Cetuximab with XELOX showed a confirmed overall RR of 50%, which was within the previously reported range of RR. The safety profile showed an acceptable rate and severity of adverse events. In light of the several advantages of XELOX, including convenience and the reported cost-saving aspects, furth …Jun 14, 2011 · We report updated overall survival (OS) data from study NO16966, which compared capecitabine plus oxaliplatin (XELOX) vs 5-fluorouracil/folinic acid plus oxaliplatin (FOLFOX4) as first-line ... 10.3109/07357907.2015.1104689. This meta-analysis aims to evaluate chemotherapy with XELOX (capecitabine plus oxaliplatin) versus FOLFOX (fluorouracil plus oxaliplatin) as a treatment for metastatic colorectal cancer (mCRC) in terms of efficacy and safety. Only randomized controlled trials (RCTs) comparing XELOX versus FOLFOX were included. Sep 21, 2016 · Purpose Capecitabine has demonstrated high efficacy as first-line treatment for metastatic colorectal cancer (MCRC). Oxaliplatin shows synergy with fluorouracil (FU), with little toxicity overlap. The XELOX regimen (capecitabine plus oxaliplatin), established in a previous dose-finding study, should improve on infused oxaliplatin with FU and leucovorin (FOLFOX) regimens. The present studies ... Jan 12, 2008 · 따라서 현재 젬시타빈 기반의 항암치료에 병이 진행한 국소진행성 혹은 전이성 췌장암 환자에서 2차 치료로서 폴폭스, 젤록스 및 젤로다 단독 항암치료를 사용해 볼 수 있다. 존재하지 않는 이미지입니다. 투여 계획은 일반적으로 세 가지 항암제를 2~3일 동안 매 ... These drugs are designed to slow the growth and kill colon cancer by damaging the DNA of these rapidly dividing cells. Goals of therapy: Capecitabine + oxaliplatin can be given to shrink tumors and decrease symptoms of colon cancer. If colon cancer is early stage (limited to intestine tissue or surrounding lymph nodes), it is commonly given ...Xerox VersaLink B7100 Series Multifunction Printers. Xerox ® ConnectKey ® technology enabled Workplace Assistant that can do it all. Black-and-white MFP with support for Tabloid. Copy, print, scan, fax, email, cloud. Tablet-like intuitive user interface lets you personalize, simplify and speed through repetitive tasks.4014 Background: At present, there is no standard chemotherapy regimen for advanced gastric cancer (AGC), and there is no consensus whether the three-drug combination is better than two-drug combination in first-line treatment. Both of XELOX regimen and EOX regimen are widely recommended as firs-line chemotherapy regimens for AGC. In this EXELOX trial, we aimed to compare the efficacy and ... Too help even it out I decided to pick up a guy's onlyfans! That guy is leo aka xleox and he is a mostly male onlyfans creator. He does some guy girl stuff m...Oct 16, 2019 · The mXELOX adjuvant chemotherapy presented a comparable survival benefit and lower incidence of toxicity than standard XELOX chemotherapy. It could be an alternative treatment for high-risk patients with operated stage III colon cancer. At least 1 in 5 individuals receiving FOLFOX treatment develop some or all of the following side effects: gastrointestinal issues, such as diarrhea, nausea, and vomiting. neurological issues, such ...2 Take your capecitabine (morning and evening) 3 Take your capecitabine (morning and evening) 4 Take your capecitabine (morning and evening)Too help even it out I decided to pick up a guy's onlyfans! That guy is leo aka xleox and he is a mostly male onlyfans creator. He does some guy girl stuff m...67K Followers, 20 Following, 50 Posts - See Instagram photos and videos from (@xleoxdaily) Sep 21, 2016 · Purpose Capecitabine has demonstrated high efficacy as first-line treatment for metastatic colorectal cancer (MCRC). Oxaliplatin shows synergy with fluorouracil (FU), with little toxicity overlap. The XELOX regimen (capecitabine plus oxaliplatin), established in a previous dose-finding study, should improve on infused oxaliplatin with FU and leucovorin (FOLFOX) regimens. The present studies ... Xerox VersaLink B7100 Series Multifunction Printers. Xerox ® ConnectKey ® technology enabled Workplace Assistant that can do it all. Black-and-white MFP with support for Tabloid. Copy, print, scan, fax, email, cloud. Tablet-like intuitive user interface lets you personalize, simplify and speed through repetitive tasks. XELOX is the code name of your cancer treatment regimen. A regimen is a combination of medications to treat cancer. This regimen name is made up of one or more letters from the names of the 2 medications in your treatment. Treatment is divided into cycles. Each cycle is 3 weeks long. The IDEA clinical consensus recommends a risk-based approach in deciding on the duration of adjuvant therapy. [6,7] For patients with low-risk stage III colon cancer (T1-3, N1), 3 months of CAPOX adjuvant chemotherapy is appropriate. For patients with high-risk stage III colon cancer (T4 and/or N2 or other high-risk factors), 6 months of ...The IDEA clinical consensus recommends a risk-based approach in deciding on the duration of adjuvant therapy. [6,7] For patients with low-risk stage III colon cancer (T1-3, N1), 3 months of CAPOX adjuvant chemotherapy is appropriate. For patients with high-risk stage III colon cancer (T4 and/or N2 or other high-risk factors), 6 months of ...My xeloda was combined with radation and Folfox with oxi and was used later after surgery. Folfox with oxi is cummulative so be aware of cold things. It is tolerable but very, very hard on the system. It will give fatigue, possible bathroom issues, and other symptoms. Good luck and wishing you well.4001 Background: The combination of PD-1 antibody and chemotherapy was shown to be effective in advanced gastric or gastro-oesophageal junction (GEJ) cancer, but has not yet been investigated in the context of locally advanced patients. In this study, we conducted a prospective, randomized, open-label phase II trial to evaluate the effectiveness of adding PD-1 antibody to perioperative ...Jul 8, 2020 · Too help even it out I decided to pick up a guy's onlyfans! That guy is leo aka xleox and he is a mostly male onlyfans creator. He does some guy girl stuff m... Bevacizumab significantly improves survival when added to chemotherapy for metastatic colorectal cancer (mCRC). The Bevacizumab Expanded Access Trial (BEAT) evaluated the safety and efficacy of bevacizumab plus first-line chemotherapy in a general cohort of patients with mCRC. The latest tweets from @onlyleox Purpose Capecitabine has demonstrated high efficacy as first-line treatment for metastatic colorectal cancer (MCRC). Oxaliplatin shows synergy with fluorouracil (FU), with little toxicity overlap. The XELOX regimen (capecitabine plus oxaliplatin), established in a previous dose-finding study, should improve on infused oxaliplatin with FU and leucovorin (FOLFOX) regimens. The present studies ...Xerox VersaLink B7100 Series Multifunction Printers. Xerox ® ConnectKey ® technology enabled Workplace Assistant that can do it all. Black-and-white MFP with support for Tabloid. Copy, print, scan, fax, email, cloud. Tablet-like intuitive user interface lets you personalize, simplify and speed through repetitive tasks.XLeox @iamxleox. Fitness Onlyfans Adult Massdm Xleox Shoutout. Description. Oner of the biggest Onlyfans male pages with over 30K fans in total (7K paid atm) https ... The latest tweets from @onlyleoxFeb 25, 2022 · There is no consensus on whether triplet regimen is better than doublet regimen in the first‐line treatment of advanced gastric cancer (AGC). We aimed to compare the efficacy and safety of oxaliplatin plus capecitabine (XELOX) and epirubicin, ... Jun 27, 2023 · Common Xeloda side effects may include: nausea, vomiting, diarrhea, stomach pain; feeling weak or tired; hand and foot syndrome; or. jaundice. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Sep 21, 2016 · Purpose Capecitabine has demonstrated high efficacy as first-line treatment for metastatic colorectal cancer (MCRC). Oxaliplatin shows synergy with fluorouracil (FU), with little toxicity overlap. The XELOX regimen (capecitabine plus oxaliplatin), established in a previous dose-finding study, should improve on infused oxaliplatin with FU and leucovorin (FOLFOX) regimens. The present studies ... XLEOX | Ownership - FidelityFULL PRESCRIBING INFORMATION . WARNING: HYPERSENSITIVITY REACTIONS, INCLUDING ANAPHYLAXIS . Serious and fatal hypersensitivity adverse reactions, including anaphylaxis, can occur Subscribe to be the first to know about new content.. @Iamxleox. Telegram channel 🔞Bevacizumab significantly improves survival when added to chemotherapy for metastatic colorectal cancer (mCRC). The Bevacizumab Expanded Access Trial (BEAT) evaluated the safety and efficacy of bevacizumab plus first-line chemotherapy in a general cohort of patients with mCRC. Too help even it out I decided to pick up a guy's onlyfans! That guy is leo aka xleox and he is a mostly male onlyfans creator. He does some guy girl stuff m...Buying romeo twinks onlyfans so you don't have to My OF: https://linktr.ee/stanchrisromeo ig: @romeo18_private🌈Become a member for a shoutout in every video...Objective: The combination of oxaliplatin and oral capecitabine (XELOX) has shown to be an active regimen in metastatic colorectal cancer (MCRC). However, the experience with XELOX in elderly patients is limited.Introduction. Gastric cancer (GC) is one of the most common malignancies in the world, with an annual incidence of about one million, making it the fifth most common cancer and the third leading cause of cancer-related deaths worldwide. 1, 2 The highest rates of estimated morbidity and mortality have been observed in Eastern Asian countries. 1Background: Preoperative chemotherapy improves the outcome in patients with colorectal cancer with liver metastases. In the current study, the authors evaluated the activity of a conversion treatment with the combination of capecitabine plus oxaliplatin (XELOX) used in association with panitumumab in patients with unresectable, liver-only, metastatic colon cancer.Oxaliplatin and capecitabine (XELOX) Oxaliplatin and capecitabine is a chemotherapy combination known as XELOX. This combination might also be called CAPOX, CAPE-OX or OxCap. It is a treatment for bowel cancer (colorectal cancer). 2 Take your capecitabine (morning and evening) 3 Take your capecitabine (morning and evening) 4 Take your capecitabine (morning and evening)
My xeloda was combined with radation and Folfox with oxi and was used later after surgery. Folfox with oxi is cummulative so be aware of cold things. It is tolerable but very, very hard on the system. It will give fatigue, possible bathroom issues, and other symptoms. Good luck and wishing you well. . Brazzers add video
Subscribe to be the first to know about new content.. @Iamxleox. Telegram channel 🔞Background: Preoperative chemotherapy improves the outcome in patients with colorectal cancer with liver metastases. In the current study, the authors evaluated the activity of a conversion treatment with the combination of capecitabine plus oxaliplatin (XELOX) used in association with panitumumab in patients with unresectable, liver-only, metastatic colon cancer.Mar 29, 2022 · At least 1 in 5 individuals receiving FOLFOX treatment develop some or all of the following side effects: gastrointestinal issues, such as diarrhea, nausea, and vomiting. neurological issues, such ... 따라서 현재 젬시타빈 기반의 항암치료에 병이 진행한 국소진행성 혹은 전이성 췌장암 환자에서 2차 치료로서 폴폭스, 젤록스 및 젤로다 단독 항암치료를 사용해 볼 수 있다. 존재하지 않는 이미지입니다. 투여 계획은 일반적으로 세 가지 항암제를 2~3일 동안 매 ...XELOX (or CAPOX) is used to treat bowel cancer. It is best to read this information with our general information about chemotherapy and the type of cancer you have. XELOX and CAPOX are different names for the same combination of chemotherapy drugs. They are named after the initials of the drugs used for treatment.Description. Oner of the biggest Onlyfans male pages with over 30K fans in total (7K paid atm) https://onlyfans.com/xleox https://onlyfans.com/iamxleox. OnlyFans.We would like to show you a description here but the site won’t allow us.BackgroundOur previous study reported the favorable efficacy and good tolerance associated with a modified XELOX adjuvant chemotherapy with eight cycles of capecitabine and six cycles of oxaliplatin for operated stage III colon cancer. The current study aimed to confirm the feasibility of modified XELOX chemotherapy for treating specific high-risk (T4, N2, or both) stage III colon cancer ...We report updated overall survival (OS) data from study NO16966, which compared capecitabine plus oxaliplatin (XELOX) vs 5-fluorouracil/folinic acid plus oxaliplatin (FOLFOX4) as first-line ...The latest tweets from @onlyleox 4001 Background: The combination of PD-1 antibody and chemotherapy was shown to be effective in advanced gastric or gastro-oesophageal junction (GEJ) cancer, but has not yet been investigated in the context of locally advanced patients. In this study, we conducted a prospective, randomized, open-label phase II trial to evaluate the effectiveness of adding PD-1 antibody to perioperative ...Outpatients with histologically confirmed colorectal cancer that was metastatic and had progressed during or within 6 months after first-line chemotherapy for metastatic disease with an irinotecan-based regimen (i.e. irinotecan plus 5-FU/FA or irinotecan, 5-FU/FA and a targeted biological agent) were enrolled. Jun 6, 2015 · AIM: To confirm the efficacy and safety of bevacizumab/XELOX combination for the treatment of locally advanced or metastatic colorectal cancer (CRC) in Italy.METHODS: This multicentric, prospective, open-label study included patients with CRC previously ... .